Diazepam is usually employed with other drugs to take care of muscle mass spasms and seizure Ailments in folks a minimum of 6 months aged.

fentanyl transdermal and diazepam both of those raise sedation. Prevent or Use Alternate Drug. Restrict use to clients for whom choice therapy options are insufficient

nevirapine will minimize the extent or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

As diazepam rectal gel is barely intended for adjunctive use, the prescriber need to ensure that the client is receiving an exceptional routine of ordinary anti-epileptic drug treatment and it is, Yet, continuing to working experience these characteristic episodes

environmentally friendly tea decreases effects of diazepam by pharmacodynamic antagonism. Minimal/Significance Unknown. Caffeine component of green tea may possibly reduce sedative consequences of benzodiazepines.

enasidenib will boost the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Enasidenib (a weak CYP2C19 inhibitor) may well improve systemic publicity of sensitive CYP2C19 substrates. Keep track of and adjust dose of substrate as clinically indicated.

Notify clients and caregivers that likely fatal additive effects might take place if diazepam is made use of with opioids Which this kind of medicine really should not be made use of concomitantly unless supervised by a wellness treatment supplier

diazepam will get more info increase the amount or effect of lemborexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Decreased nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for distinct dosage modification.

Steer clear of or substitute A different drug for these drugs when feasible. Appraise for loss of therapeutic effect if medication has to be coadministered. Modify dose In keeping with prescribing data if needed.

Check Closely (one)triclabendazole will boost the amount or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism.

Diazepam drug misuse can occur both as a result of recreational misuse where by the drug is taken to achieve a significant or once the drug is ongoing long-lasting against professional medical guidance.[one hundred thirty]

Diazepam could be quantified in blood or plasma to confirm a analysis of poisoning in hospitalized individuals, deliver proof in an impaired driving arrest, or to assist in a very medicolegal Demise investigation. Blood or plasma diazepam concentrations are often in A variety of 0.

Pitfalls of dependence and withdrawal maximize with more time therapy length and better everyday dose; Despite the fact that injection is indicated just for intermittent use, if utilized additional regularly than proposed, abrupt discontinuation or speedy dosage reduction may perhaps precipitate acute

apalutamide will minimize the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications that are CYP3A4 substrates can lead to reduced exposure to these medicines.